解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.03.005
更新日期:2008-06-01 00:00:00
abstract::Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.01.020
更新日期:2008-04-01 00:00:00
abstract::Interleukin (IL)-1 gene polymorphisms affect several inflammatory diseases, including cancer. Therefore, we studied genetic association of biallelic (-511C>T) polymorphism of IL-1 beta and 86-bp VNTR polymorphism of IL-1RN in 159 patients with esophageal cancer (EC) and 194 age- and gender-matched healthy controls. Ge...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.01.012
更新日期:2008-03-01 00:00:00
abstract::Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.12.004
更新日期:2008-02-01 00:00:00
abstract::The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms a...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.01.008
更新日期:2008-02-01 00:00:00
abstract::The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.11.001
更新日期:2008-01-01 00:00:00
abstract::The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.09.003
更新日期:2007-11-01 00:00:00
abstract::Neem leaf preparation (NLP) was found to activate natural killer (NK) cells (CD56(+)CD3(-)) to enhance their cytotoxic ability to tumor cells and stimulate the release of interleukin-12 (IL-12) from macrophages from healthy individuals and head-and-neck squamous cell carcinoma patients. NLP upregulated cytotoxic (CD16...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.08.002
更新日期:2007-10-01 00:00:00
abstract::A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.06.003
更新日期:2007-09-01 00:00:00
abstract::The aim of this work was to investigate the longitudinal evolution of plasmatic soluble HLA-G (sHLA-G: shed HLA-G1 plus HLA-G5) during pregnancy, and if peripheral maternal antigen presenting cells (APC) can be a source of sHLA-G. Blood samples were obtained from 45 volunteers during normal pregnancy, 8 of them monthl...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.04.007
更新日期:2007-08-01 00:00:00
abstract::Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.03.010
更新日期:2007-07-01 00:00:00
abstract::Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.02.001
更新日期:2007-06-01 00:00:00
abstract::The T-helper 1 (Th1) immune reaction is most important in dendritic cell (DC)-based immunotherapy. Interleukin (IL)-18, a Th1-biasing cytokine, plays a pivotal role in inducing cytotoxic T lymphocyte (CTL) responses. In this study, we analyzed whether dendritic cells (DCs) from patients with hepatocellular carcinoma (...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.01.008
更新日期:2007-05-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.01.011
更新日期:2007-05-01 00:00:00
abstract::Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.11.003
更新日期:2007-04-01 00:00:00
abstract::Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.12.008
更新日期:2007-03-01 00:00:00
abstract::The C-type lectins DC-SIGN and L-SIGN are important pathogen-recognition receptors of the human innate immune system. Both lectins have been shown to interact with a vast range of infectious agents, including Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. In addition, DC-SIGN and L-SIGN pos...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.10.020
更新日期:2007-02-01 00:00:00
abstract::The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.09.004
更新日期:2007-01-01 00:00:00
abstract::Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.10.007
更新日期:2006-12-01 00:00:00
abstract::The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.08.297
更新日期:2006-11-01 00:00:00
abstract::To evaluate the role of tumor necrosis factor-alpha (TNF-alpha) gene as susceptibility marker for spondyloarthritis (SpA), two polymorphisms (-238 and -308 positions) were analyzed in 229 patients with SpA (113 with ankylosing spondylitis [AS], 92 with undifferentiated SpA [U-SpA], 24 with reactive arthritis), and 169...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.07.009
更新日期:2006-10-01 00:00:00
abstract::Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.05.005
更新日期:2006-09-01 00:00:00
abstract::Celiac disease (CD) follows an autoimmune course in which both genetic and environmental factors contribute to its development. A strong association with HLA class II molecules, predominantly HLA-DQ2, has been reported in most ethnic groups with CD. The aim of this study was to determine if genetic polymorphisms in L-...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.05.001
更新日期:2006-08-01 00:00:00
abstract::Cord blood, donated by mothers after the birth of their children, has become an accepted source of related and unrelated hematopoietic stem cells for marrow reconstitution. We estimate that some 7-8000 unrelated-donor cord blood transplants have been performed worldwide since 1993. The development of cord blood as a s...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2006.03.015
更新日期:2006-06-01 00:00:00
abstract::Celiac disease (CD) patients are intolerant to gluten, proteins in wheat, and related cereals. Virtually all patients are human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positive and several studies have demonstrated that CD4 T cells specific for (modified) gluten peptides bound to these HLA-DQ molecules are found in pat...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2006.03.011
更新日期:2006-06-01 00:00:00
abstract::Several risk factors including immune deficiencies, infections, and autoimmune diseases have been established for non-Hodgkin's lymphoma (NHL). For diffuse large B cell lymphoma (DLBCL), the most common type of lymphoma, no risk factors have been described, which may be due to the intrinsic heterogeneity of this disor...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.03.019
更新日期:2006-04-01 00:00:00
abstract::HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.038
更新日期:2006-04-01 00:00:00
abstract::The polymorphic MICA gene encodes glycoproteins that activate T cells and NK cells through the NKG2D receptor and may costimulate immune functions. We found that MICA was expressed on freshly isolated human fibroblasts and was markedly decreased when fibroblasts were grown to confluency in culture dishes. MICA surface...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.018
更新日期:2006-03-01 00:00:00
abstract::Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.03.018
更新日期:2006-01-01 00:00:00
abstract::To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICA5 was significantly increased in the T1D patient grou...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.032
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to test whether the functional variant rs2076530 of the BTNL2 gene confers susceptibility to the autoimmune diseases type 1 diabetes (T1D), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Our study populations consisted of 326 patients with T1D and 351 healthy subjects, 808...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.003
更新日期:2005-12-01 00:00:00
abstract::The occurrence of graft rejection episodes after orthotopic liver transplantation (OLT) despite the use of immunosuppressive drugs designed to suppress T lymphocyte functions, indicates the involvement of other types of cells in this process. The activity of natural killer cells and their killer immunoglobulin-like re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.10.016
更新日期:2005-11-01 00:00:00
abstract::Only 10% of persons infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB), indicating the existence of host genetic factors regulating disease expression. We investigated the association of human leukocyte antigen (HLA) class II genes with the susceptibility to pulmonary TB in Koreans, with speci...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.08.242
更新日期:2005-10-01 00:00:00
abstract::We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.07.001
更新日期:2005-09-01 00:00:00
abstract::The aim of this study was to assess the possible association of the functional (GT)(n) microsatellite polymorphism in the FOXP3 gene with predisposition to several autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease, and celiac disease. We...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.06.001
更新日期:2005-08-01 00:00:00
abstract::Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.04.003
更新日期:2005-07-01 00:00:00
abstract::Induction of donor type chimerism in mildly prepared hosts without graft-versus-host disease (GvHD) is a most desirable goal in bone morrow transplantation. We have recently demonstrated in a mouse model that donor veto cytotoxic T lymphocytes (CTLs) can facilitate the induction of donor type chimerism in sublethally ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.03.004
更新日期:2005-06-01 00:00:00
abstract::Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 and -DQB1 associations with GD in 198 Korean patients compared with 200 he...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.03.001
更新日期:2005-06-01 00:00:00
abstract::On waiting lists, transplant candidates are routinely screened for potentially harmful complement-fixing alloantibodies using complement-dependent cytotoxicity (CDC) panel-reactive antibody (PRA) testing. We have recently developed a novel cell-independent assay for assessment of complement-activating panel reactivity...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.12.007
更新日期:2005-05-01 00:00:00
abstract::There is increased evidence about the deleterious effect of delayed graft function (DGF) in both short- and long-term kidney graft outcome. Among the mechanisms involved in the production of DGF, immune factors play a role, especially in the level of hypersensitization. From the 1389 patients transplanted at our hospi...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2005.01.026
更新日期:2005-04-01 00:00:00